Vertebrate testing under REACH is discouraged by promoting use of alternative non-testing approaches such as QSARs (Quantitative Structure Activity Relationships). Many QSARs are available. However, robust REACH compliant QSARs predicting chronic ecotoxicity to fish are largely lacking.
ARCHE developed a QSAR to predict chronic toxicity to fish, based on high quality data. The developed models are compliant with the OECD principles and can be used as part of a registration dossier and classification. Using a chronic QSAR for long-term fish ecotoxicity, one can refine the hazard classification and PNEC derivation for polar and non-polar narcosis substances.
One of the 5 OECD criteria is transparency of the QSAR. Therefore, the training and test set for both non-polar and polar narcosis are publically available. These datasets are included as extra sheets to the QSARCHE Excel tool.
This tool is freely available. Any feedback is highly appreciated (please send your comments to Lieve Claeys at email@example.com).