QSARCHE (Quantitative structure activity relationship for chemicals' ecotoxicity)
Vertebrate testing under REACH is discouraged by promoting use of alternative non-testing approaches such as QSARs (Quantitative Structure Activity Relationships). Many QSARs are available. However, robust REACH compliant QSARs predicting chronic ecotoxicity to fish are largely lacking.
ARCHE developed a QSAR to predict chronic toxicity to fish, based on high quality data. The developed models are compliant with the OECD principles and can be used as part of a registration dossier and classification. Using a chronic QSAR for long-term fish ecotoxicity, one can refine the hazard classification and PNEC derivation for polar and non-polar narcosis substances.
One of the 5 OECD criteria is transparency of the QSAR. Therefore, the training and test set for both non-polar and polar narcosis are publically available. These datasets are included as extra sheets to the QSARCHE Excel tool.
This tool is freely available. Any feedback is highly appreciated (please send your comments to Lieve Claeys at email@example.com.
Keep track of our latest news
New Soil PNEC calculator is available!
A new updated version of the soil PNEC calculator is available for download on our website. Apart from a new layout, this new version now also includes data for Co and Mo. All calculations are now based on the data and methods selected for the EU REACH dossiers (Registration, Evaluation, Authorisation and Restriction of Chemicals; Regulation EC No 1907/2006) for Cu, Ni, Zn, Pb, Cd, Mo and Co, as available in August 2012."
From Soil screening values to Metal Clean-up values
Dr. Koen Oorts (ARCHE) is invited by the North American Metals Council (NAMC) to actively participate in a workshop on "Ecological Soil Levels-Next Steps in the Development of Metal Clean-up Values" scheduled for September 17-20, 2012 in Utah. The workshop's main goal is to provide regulators with the methods and processes developed over the last ten years to move from soil screening values to clean-up values.
SPERC tool for metals is updated!
The first version of the metal SPERCs was published in 2010 for the purpose of the 2010 REACH registration deadline and underwent a review process conducted by Lüskow et al. (2011) on behalf of the Federal Environment Agency of Germany (UBA). The second version of the metal SPERCs were improved based on the recommendations by Lüskow et al. (2011) and Tolls et al. (in press) and were further updated with new data for the purpose of the 2013 REACH registration deadline. This second version is currently undergoing a scientific review process but can already been find on this website.
Our QSARCHE model is released
Vertebrate testing under REACH is discouraged by promoting use of alternative non-testing approaches such as QSARs (Quantitative Structure Activity Relationships). Many QSARs are available, however, robust REACH compliant QSARs predicting chronic ecotoxicity to fish are largely lacking. ARCHE filled this data gap by the release of its QSARCHE fish toxicity model. Click to the right to read on.
Meet us at these upcoming events
4th Symposium on Biocidal Product Authorisation Vienna 23-24 May 2013
Symposium on authorisation/registration of biocidal products according to existing schemes(especially BPD) and the arising issues and interaction with the forthcoming Biocidal ProductRegulation (BPR)
65th International Symposium on crop protection- 21-05-2013 Ghent
This Symposium will be held at the Faculty of Bioscience Engineering of the Ghent University, Coupure links 653, BE-9000 Ghent, Belgium.